Antithrombin-lowering in hemophilia: a closer look at fitusiran
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Summer 2022 haemophilia trial update - European Pharmaceutical Review
Michael Makris on X: Robert Klamroth presented the results of the phase 3 Fitusiran study. This is siRNA inhibition of antithrombin in #hemophilia with no inhibitors. 90% reduction in ABR (Primary endpoint).
Targeting of antithrombin in hemophilia A or B with investigational siRNA therapeutic fitusiran—Results of the phase 1 inhibitor cohort - Pasi - 2021 - Journal of Thrombosis and Haemostasis - Wiley Online Library
Antithrombin-lowering in hemophilia: a closer look at fitusiran - ScienceDirect
Antithrombin-lowering in hemophilia: a closer look at fitusiran - Research and Practice in Thrombosis and Haemostasis
Positive Phase III results for fitusiran in hemophilia
Tailoring the effect of antithrombin-targeting therapy in haemophilia A using in silico thrombin generation
RNAi for the treatment of people with hemophilia
Fitusiran Substantially Reduces Hemophilia Bleeds with Simple Monthly Injection
Gene therapy in haemophilia: literature review and regional perspectives for Turkey - Kaan Kavaklı, Bülent Antmen, Vahap Okan, Fahri Şahin, Selin Aytaç, Can Balkan, Ergül Berber, Zühre Kaya, Alphan Küpesiz, Bülent Zülfikar