Viruses, Free Full-Text

Por um escritor misterioso

Descrição

The respiratory epithelium, particularly the airway epithelium, is the primary infection site for respiratory pathogens. The apical surface of epithelial cells is constantly exposed to external stimuli including invading pathogens. Efforts have been made to establish organoid cultures to recapitulate the human respiratory tract. However, a robust and simple model with an easily accessible apical surface would benefit respiratory research. Here, we report the generation and characterization of apical-out airway organoids from the long-term expandable lung organoids that we previously established. The apical-out airway organoids morphologically and functionally recapitulated the human airway epithelium at a comparable level to the apical-in airway organoids. Moreover, apical-out airway organoids sustained productive and multicycle replication of SARS-CoV-2, and accurately recapitulated the higher infectivity and replicative fitness of the Omicron variants BA.5 and B.1.1.529 and an ancestral virus. In conclusion, we established a physiologically relevant and convenient apical-out airway organoid model for studying respiratory biology and diseases.
Viruses, Free Full-Text
Listen Free to Viruses: A Very Short Introduction by Dorothy H
Viruses, Free Full-Text
How to Create a Virus: 9 Steps (with Pictures) - wikiHow
Viruses, Free Full-Text
How to Tell If You Have a Computer Virus
Viruses, Free Full-Text
Frontiers Pandemics Throughout History
Viruses, Free Full-Text
Viruses, Free Full-Text
Viruses, Free Full-Text
Ebola
Viruses, Free Full-Text
Cartoon viruses. Germs virus character, funny bacteria types
Viruses, Free Full-Text
Viruses take center stage in cellular evolution
Viruses, Free Full-Text
5 Best Free Online Virus Scanners & Removers for 2023
Viruses, Free Full-Text
Remove Viruses Detected (5) Pop-up Scam [Virus Removal]
Viruses, Free Full-Text
Malwarebytes Free: Free Antivirus 2024
Viruses, Free Full-Text
The Top 10 Worst Computer Viruses in History
de por adulto (o preço varia de acordo com o tamanho do grupo)