Pharmaceutics, Free Full-Text
Por um escritor misterioso
Descrição
Viral and synthetic vectors to deliver nucleic acids were key to the rapid development of extraordinarily efficient COVID-19 vaccines. The four-component lipid nanoparticles (LNPs), containing phospholipids, PEG-conjugated lipids, cholesterol, and ionizable lipids, co-assembled with mRNA via a microfluidic technology, are the leading nonviral delivery vector used by BioNTech/Pfizer and Moderna to access COVID-19 mRNA vaccines. LNPs exhibit a statistical distribution of their four components when delivering mRNA. Here, we report a methodology that involves screening libraries to discover the molecular design principles required to realize organ-targeted mRNA delivery and mediate activity with a one-component ionizable multifunctional amphiphilic Janus dendrimer (IAJD) derived from plant phenolic acids. IAJDs co-assemble with mRNA into monodisperse dendrimersome nanoparticles (DNPs) with predictable dimensions, via the simple injection of their ethanol solution in a buffer. The precise location of the functional groups in one-component IAJDs demonstrated that the targeted organs, including the liver, spleen, lymph nodes, and lung, are selected based on the hydrophilic region, while activity is associated with the hydrophobic domain of IAJDs. These principles, and a mechanistic hypothesis to explain activity, simplify the synthesis of IAJDs, the assembly of DNPs, handling, and storage of vaccines, and reduce price, despite employing renewable plant starting materials. Using simple molecular design principles will lead to increased accessibility to a large diversity of mRNA-based vaccines and nanotherapeutics.
Few Blisters Stock Photos - 850 Images
REMfresh Melatonin Sleep Supplement, Drug-Free, Pills to Support Natural Sleep, #1
Personalized Pharmaceutical Credit Card Flash Drive - 16 GB Memory
Journal of the American Pharmaceutical Association 1933-11: Vol 22 Iss 11 : Free Download, Borrow, and Streaming : Internet Archive
International Journal of Pharmaceutics
30+ Closed Door Pharmacy Stock Photos, Pictures & Royalty-Free Images - iStock
The pharmaceutical codex : principles and practice of pharmaceutics : Free Download, Borrow, and Streaming : Internet Archive
Free Reference Letter For Pharmacy Technician - Download in Word, Google Docs, PDF, Apple Pages
Three Birds, One Excipient: Development of an Improved pH, Isotonic, and Buffered Ketamine Formulation for Subcutaneous Injection—Pharmaceutics
Dota 6.64 Ai Plus - Colaboratory
Top view of colorful tablets and capsule pills in blister packaging arrange with beautiful pattern. Pharmaceutical industry concept. Full frame pills background. Global pharmaceuticals. Defective. 7774187 Stock Photo at Vecteezy
PSOAR & PGIAR: The Blog & Custom Search Engines: International Journal of Applied Biology and Pharmaceutical Technology [Open Access]
Extemporaneous Compounding, PDF, Pharmaceutical Drug
QUALITY CONTROL OF PHARMACEUTICALS. - Abstract - Europe PMC
