Molecules, Free Full-Text

Por um escritor misterioso

Descrição

COVID-19 is an acute respiratory disease caused by SARS-CoV-2 that has spawned a worldwide pandemic. ADAM17 is a sheddase associated with the modulation of the receptor ACE2 of SARS-CoV-2. Studies have revealed that malignant phenotypes of several cancer types are closely relevant to highly expressed ADAM17. However, ADAM17 regulation in SARS-CoV-2 invasion and its role on small molecules are unclear. Here, we evaluated the ADAM17 inhibitory effects of cordycepin (CD), thymoquinone (TQ), and N6, N6-dimethyladenosine (m62A), on cancer cells and predicted the anti-COVID-19 potential of the three compounds and their underlying signaling pathways by network pharmacology. It was found that CD, TQ, and m62A repressed the ADAM17 expression upon different cancer cells remarkably. Moreover, CD inhibited GFP-positive syncytia formation significantly, suggesting its potential against SARS-CoV-2. Pharmacological analysis by constructing CD-, TQ-, and m62A-based drug-target COVID-19 networks further indicated that ADAM17 is a potential target for anti-COVID-19 therapy with these compounds, and the mechanism might be relevant to viral infection and transmembrane receptors-mediated signal transduction. These findings imply that ADAM17 is of potentially medical significance for cancer patients infected with SARS-CoV-2, which provides potential new targets and insights for developing innovative drugs against COVID-19.
Molecules, Free Full-Text
55+ Thousand Chemistry Text Royalty-Free Images, Stock Photos
Molecules, Free Full-Text
Synthesis of Azonia Aromatic Heterocycles Bearing 6–6–6–5–6
Molecules, Free Full-Text
PDF] Molecules and Medicine by E. J. Corey eBook
Molecules, Free Full-Text
Molecules, Free Full-Text
Molecules, Free Full-Text
Lagu Xiao Wei Get File - Colaboratory
Molecules, Free Full-Text
Molecules Set of 4 Art PRINTABLES Caffeine Happiness Sleep
Molecules, Free Full-Text
Molecules, Free Full-Text
Molecules, Free Full-Text
How To Determine Hybridization: A Shortcut – Master Organic Chemistry
Molecules, Free Full-Text
Molecules, Free Full-Text
Molecules, Free Full-Text
Molecules, Free Full-Text
Molecules, Free Full-Text
Sample molecules. Chemozart generates high-quality molecular
Molecules, Free Full-Text
European Pharmacopoeia 6.0 Free Download - Colaboratory
Molecules, Free Full-Text
Biocatalytic Construction of Chiral Pyrrolidines and Indolines via
de por adulto (o preço varia de acordo com o tamanho do grupo)