Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond
Por um escritor misterioso
Descrição
Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).
Aberrant RNA translation in fragile X syndrome: From FMRP
Fragile X syndrome: From protein function to therapy - Bagni
Protein synthesis as a modifiable target for autism‐related
The molecular biology of FMRP: new insights into fragile X
Mechanism-Based Treatments in Neurodevelopmental Disorders
Therapeutic Strategies in Fragile X Syndrome: Dysregulated mGluR
Co-Translational Folding: A Novel Modulator of Local Protein
Molecular mechanisms behind mRNA localization in axons
Excess Translation of Epigenetic Regulators Contributes to Fragile
