IJMS, Free Full-Text

Por um escritor misterioso

Descrição

While platelet function has traditionally been described in the context of maintaining vascular integrity, recent evidence suggests that platelets can modulate inflammation in a much more sophisticated and nuanced manner than previously thought. Some aspects of this expanded repertoire of platelet function are mediated via expression of Toll-like receptors (TLRs). TLRs are a family of pattern recognition receptors that recognize pathogen-associated and damage-associated molecular patterns. Activation of these receptors is crucial for orchestrating and sustaining the inflammatory response to both types of danger signals. The TLR family consists of 10 known receptors, and there is at least some evidence that each of these are expressed on or within human platelets. This review presents the literature on TLR-mediated platelet activation for each of these receptors, and the existing understanding of platelet-TLR immune modulation. This review also highlights unresolved methodological issues that potentially contribute to some of the discrepancies within the literature, and we also suggest several recommendations to overcome these issues. Current understanding of TLR-mediated platelet responses in influenza, sepsis, transfusion-related injury and cardiovascular disease are discussed, and key outstanding research questions are highlighted. In summary, we provide a resource—a “researcher’s toolkit”—for undertaking further research in the field of platelet-TLR biology.
IJMS, Free Full-Text
IJMS, Free Full-Text
IJMS, Free Full-Text
Fair Priced FavoriteIJMS, Free Full-Text, louis velasquez cgm
IJMS, Free Full-Text
IJMS, Free Full-Text
IJMS, Free Full-Text
IJMS, Free Full-Text
IJMS, Free Full-Text
IJMS Free Full Text Recent Insights From Molecular Dynamics Simulations For G Protein 84405
IJMS, Free Full-Text
Ijms Free Full Text Hyaluronic Acid Influence On Normal And Osteoarthritic Tissue Engineered
IJMS, Free Full-Text
IJMS Free Full-Text Research Advances In Mechanical, 54% OFF
IJMS, Free Full-Text
Ijms Free Full Text Approaching Sex Differences In Cardiovascular
IJMS, Free Full-Text
IJMS, Free Full-Text
IJMS, Free Full-Text
www.mdpi.com/ijms/ijms-13-04564/article_deploy/htm
IJMS, Free Full-Text
pka creb signaling pathway - Clip Art Library
de por adulto (o preço varia de acordo com o tamanho do grupo)