Cancers, Free Full-Text
Por um escritor misterioso
Descrição
Transforming growth factor-beta (TGFB) is a critical regulator of normal haematopoiesis. Dysregulation of the TGFB pathway is associated with numerous haematological malignancies including myelofibrosis, acute myeloid leukaemia, and lymphoid disorders. TGFB has classically been seen as a negative regulator of proliferation in haematopoiesis whilst stimulating differentiation and apoptosis, as required to maintain homeostasis. Tumours frequently develop intrinsic resistant mechanisms to homeostatic TGFB signalling to antagonise its tumour-suppressive functions. Furthermore, elevated levels of TGFB enhance pathogenesis through modulation of the immune system and tumour microenvironment. Here, we review recent advances in the understanding of TGFB signalling in B-cell malignancies with a focus on the tumour microenvironment. Malignant B-cells harbour subtype-specific alterations in TGFB signalling elements including downregulation of surface receptors, modulation of SMAD signalling proteins, as well as genetic and epigenetic aberrations. Microenvironmental TGFB generates a protumoural niche reprogramming stromal, natural killer (NK), and T-cells. Increasingly, evidence points to complex bi-directional cross-talk between cells of the microenvironment and malignant B-cells. A greater understanding of intercellular communication and the context-specific nature of TGFB signalling may provide further insight into disease pathogenesis and future therapeutic strategies.
Cancers, Free Full-Text
Home - Free ME from Lung Cancer
I Am Cancer Free! - Cancer Free Gift - Pin
The Cure for All Cancers - free download pdf - issuhub
PDF) Treatment outcome with low-dose-rate interstitial brachytherapy in early-stage oral tongue cancers
Cancer Free – Heaven Sent Greeting Cards
Frailty and prognosis in lung cancer: systematic review and meta-analysis
Cancers, Free Full-Text
Blood Test for Cancer Screening
Free Your Body of Tumors and Cysts – Hanna's Herb Shop
Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer
Predicting peritoneal recurrence and disease-free survival from CT images in gastric cancer with multitask deep learning: a retrospective study - The Lancet Digital Health
Free PSD Breast cancer awareness editable text effect
Multi-omics integrated circulating cell-free DNA genomic signatures enhanced the diagnostic performance of early-stage lung cancer and postoperative minimal residual disease - eBioMedicine
